Different Routes of Drugs Administration in Mice/Rats.

There are several routes of drug administration that can be used depending on the specific research objectives and the properties of the drug. 

Here are some common routes of drug administration in mice and rats: 

Fig. Different Routes of Drug Administrations

 1. Oral Administration: This is one of the most common routes of drug administration. The drug is administered through the mouth using techniques such as gavage (using a specially designed tube) or mixing the drug with food or drinking water. This route is convenient and mimics oral drug intake in humans. 

 2. Intraperitoneal (IP) Injection: In this method, the drug is injected into the peritoneal cavity, which is the space surrounding the abdominal organs. This route allows for rapid absorption and is suitable for drugs that are not well-absorbed orally or need systemic distribution. 

3. Subcutaneous (SC) Injection: Subcutaneous injection involves delivering the drug into the layer of tissue just beneath the skin. It allows for slow and sustained drug absorption into the systemic circulation. This route is commonly used for drugs that require prolonged exposure or when a slower onset of action is desired.

4. Intravenous (IV) Injection: Intravenous injection involves direct administration of the drug into a vein. It provides rapid and complete drug absorption, resulting in immediate systemic distribution. This route is commonly used for precise dosing and rapid onset of action. 

5. Intramuscular (IM) Injection: Intramuscular injection involves delivering the drug into a muscle. This route allows for good drug absorption and is suitable for drugs that need prolonged release or are irritant when given by other routes. 

 6. Inhalation: Inhalation involves administering the drug in the form of a gas, vapor, or aerosol for inhalation into the respiratory system. This route is commonly used for respiratory medications or drugs that target the lungs. 

7. Topical Application: Topical application involves applying the drug directly to the skin or mucous membranes. This route is suitable for drugs that exert a localized effect, such as creams, ointments, or eye drops. 

It is important to consider the properties of the drug, its intended effects, and the research objectives when selecting the appropriate route of administration in mice and rats. Additionally, the chosen route should be in compliance with ethical guidelines and consider the well-being of the animals.

Here's a table indicating the approximate volume of drug that can be administered via different routes to mice and rats

 

Please note that the volume ranges provided are approximate and may vary depending on the specific experimental requirements, the concentration of the drug, and the size and health condition of the animals. It is important to consult the relevant scientific literature, protocols, and ethical guidelines to determine the appropriate volume for drug administration in mice and rats.

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