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Hemopoiesis

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Hemopoiesis: How Your Body Makes Blood Cells Why do we need constant blood cell production? Most blood cells live fast and die young. Many white blood cells survive only hours to days; platelets last about a week; red blood cells last around 120 days. To keep you healthy, the body must continually replace these “formed elements.” Negative feedback systems keep RBCs and platelets relatively steady, while white blood cell numbers swing up or down depending on infections, inflammation, and other immune challenges. Where does hemopoiesis happen across life? Hemopoiesis (also called hematopoiesis) is the process of forming blood cells. Early embryo: yolk sac Fetus: liver, spleen, thymus, and lymph nodes Last trimester onward and throughout life: red bone marrow becomes the primary site In newborns, almost all marrow is red and active. With growth, much of the marrow in long bones turns into yellow marrow (fatty and inactive). During severe blood loss, yellow marrow can revert to red an...
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Muscle Tissue

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Study of Effect of Drugs on Ciliary Motility of Frog Esophagus

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Introduction The study aims to investigate the effect of drugs on the ciliary motility of the frog esophagus. Ciliary motility refers to the rhythmic and coordinated movement of cilia, which are hair-like structures present on the surface of cells in the esophagus. The ciliary movement plays a crucial role in transporting mucus and other substances along the esophageal lining. Requirements Animal: Frog Drugs: Acetylcholine, Physostigmine, Atropine Physiological Salt Solution: Frog's Ringer Solution Equipment: Frog board, and Poppy seeds Procedure Decapitate the frog and pin the frog to the frog board on its back. Pin the lower jaw to the abdomen cutting sufficiently the buccal cavity and exposing the esophagus. Keep the buccal cavity and the opening of the esophagus wet by irrigating it with Ringer solution. Fix two parts i.e., first the beginning point at the beginning of the esophagus and the endpoint. Keep this distance constant to measure the time taken by the poppy seed t...
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Inflammation

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Inflammation Inflammation is a complex biological response that occurs in the body as a defense mechanism against various harmful stimuli, such as pathogens (bacteria, viruses, fungi), tissue injury, toxins, and foreign substances. It is a crucial part of the body's innate immune response, which provides the first line of defense against potential threats. Inflammation can be defined as a localized, protective response of tissues to harmful stimuli. It involves a series of coordinated events and interactions among immune cells, blood vessels, and molecular mediators that aim  To eliminate the source of injury or infection To remove damaged tissue To initiate the process of tissue repair and healing Role in the Body's Defense Mechanisms The role of inflammation in the body's defense mechanisms is multifaceted and serves several essential functions: 1. Detection and Containment of Harmful Agents When tissues are exposed to pathogens or injury, immune cells such as macrophages...
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Effect of Hepatic Microsomal Enzyme Inducers on the Phenobarbitone Sleeping Time in Mice

Aim: To study of effect of hepatic microsomal enzyme inducers on the phenobarbitone sleeping time in mice. Principle Hypnosis is a natural sleep process, and substances or medications that induce it are referred to as hypnotic agents. While this concept primarily applies to human patients, in animal experiments, the term "hypnotic" is used to describe a deeper stage of central depression that leads to unconsciousness, accompanied by the loss of righting reflexes and muscle tone.  The term "loss of righting reflex" is commonly used to describe the animal's state of "sleep," characterized by the inability to correct its posture when placed on its back. Normally, animals instinctively turn their bodies so that their paws or feet are positioned towards the ground—an action known as the righting reflex. The righting reflex relies on the proper functioning of the vestibular, visual, and proprioceptive systems.  Materials and Methods Materials Animal/species ...
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Anti-epileptics

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Epilepsy Epilepsy is a neurological disorder characterized by recurring seizures, which are episodes of abnormal electrical activity in the brain. It affects people of all ages and can have various underlying causes. Epilepsy is a chronic condition that requires ongoing management and treatment. Classification of Epilepsy Epilepsy can be classified into different types based on various factors, including the seizure type, location in the brain where seizures originate, and underlying causes. The International League Against Epilepsy (ILAE) provides a widely used classification system known as the ILAE Classification of Seizures and Epilepsies. 1. Generalized Epilepsy Generalized Seizures: Seizures that involve both sides of the brain from the onset. They can be further classified into different subtypes, including: Absence seizures: Brief loss of consciousness, often accompanied by subtle body movements. Absence seizures Tonic-clonic seizures: Characterized by muscle stiffness (toni...
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Sedatives, Hypnotics, and Centrally Acting Muscle Relaxants

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Sedatives and Hypnotics Introduction Sedatives and hypnotics are medications that act on the central nervous system (CNS) to induce relaxation, reduce anxiety, promote sleep, or produce a hypnotic state. Sedatives have a calming effect, while hypnotics induce and maintain sleep. These drugs can help manage insomnia, anxiety disorders, and certain medical procedures requiring sedation. Pharmacology of Sedative-Hypnotic Drugs Mechanism of Action Sedative-hypnotic drugs enhance the activity of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS. They bind to  GABA A receptors, increasing the influx of chloride ions into neurons, leading to neuronal hyperpolarization and suppression of neuronal activity. Fig GABAergic neurotransmission Fig Hyperpolarization Sedatives and hypnotic drugs can be classified into different categories based on their chemical structure and pharmacological properties. Here is a classification of commonly used sedatives and hypnotics 1. Be...
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